2. Signaling Pathways
  3. PROTAC
  4. Ligands for E3 Ligase

Ligands for E3 Ligase

E3 ligase-recruiting Moiety

Ligands for E3 Ligase

Related Products

PDF 1.28 MB

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder). The association between an E3 ligase and a target protein induced by a PROTAC will lead to the transfer of ubiquitin and degradation of the targeted protein.

E3 ligases catalyze the transfer of ubiquitin to targeted proteins and determine the specificity of the proteins. There are hundreds of E3 ligases in cells, but only a limited number of them are successfully used in reported PROTACs, such as VHL (von Hippel-Lindau disease tumor suppressor protein), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue) and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase Isoform Specific Products:

Ligands for E3 Ligase Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W241635
    Thalidomide acid 1547163-38-1 98.0%
    Thalidomide acid is a Thalidomide analog that can be useful in PROTAC research.
    Thalidomide acid
  • HY-W877989
    BWA-522 intermediate-1 2241315-66-0 99.27%
    BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7.
    BWA-522 intermediate-1
  • HY-W898989
    3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione 2923549-60-2 98.92%
    3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.
    3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione
  • HY-10984R
    Pomalidomide (Standard) 19171-19-8
    Pomalidomide (Standard) is the analytical standard of Pomalidomide. This product is intended for research and analytical applications. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.
    Pomalidomide (Standard)
  • HY-170428
    IPS-06061 3064065-83-1
    IPS-06061 is an orally active molecular glue forming a ternary complex of CRBN-KRASG12D-IPS06061, degrading KRASG12D with a DC50 value lower than 500 nM. IPS-06061 shows a strong anti-tumor efficacy.
    IPS-06061
  • HY-169989
    CRBN ligand-11 2962967-27-5 99.94%
    CRBN ligand-11 is the E3 ubiquitin ligase ligand for CFT8634 (HY-145925B). CRBN ligand-11 can be used for the synthesis of PROTACs.
    CRBN ligand-11
  • HY-138882A
    Lenalidomide-4-aminomethyl hydrochloride 444289-05-8
    Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
    Lenalidomide-4-aminomethyl hydrochloride
  • HY-132971
    Thalidomide-piperazine hydrochloride 2228029-82-9 98.27%
    Thalidomide-piperazine hydrochloride is a synthetic E3 ligase ligand-linker conjugate, comprising a cereblon ligand based on Thalidomide (HY-14658) and one linker. Thalidomide-piperazine hydrochloride can be used in studies related to PROTAC synthesis.
    Thalidomide-piperazine hydrochloride
  • HY-162553
    GNE7599 2771069-76-0 99.19%
    GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a Kd of 540 pM. GNE7599 can be connected to the ligand for protein by a linker to form PROTACs.
    GNE7599
  • HY-138678
    (R,S,S)-VH032 2230826-33-0 98.99%
    (R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R,S,S)-VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669).
    (R,S,S)-VH032
  • HY-W247437
    E3 ligase Ligand 56 1472731-41-1 99.88%
    E3 ligase Ligand 56 is the ligand for E3 ligase Cereblon and can be used for syntheisis of PROTAC CDK9 degrader-11 (HY-170978).
    E3 ligase Ligand 56
  • HY-168667
    E3 ligase Ligand 40 98.62%
    E3 Ligase Ligand 40 is an E3 ligase ligand and can be used for the synthesis of PROTAC molecules.
    E3 ligase Ligand 40
  • HY-139540
    Pomalidomide-6-OH 1547162-44-6 98.81%
    Pomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC.
    Pomalidomide-6-OH
  • HY-W076313
    2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione 959150-64-2 99.88%
    2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a derivative of Thalidomide with an iodine atom on the benzyl ring
    2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione
  • HY-W460227
    Lenalidomide-4-Br-7-fluoro 2438239-34-8 99.54%
    Lenalidomide-4-Br-7-fluoro is a derivative of Lenalidomide with a flouride and bromide groups on the benzyl ring.
    Lenalidomide-4-Br-7-fluoro
  • HY-W761300
    1-(4-Pip-Ph)-DHP-dione 2446913-96-6 99.04%
    1-(4-Pip-Ph)-DHP-dione is an E3 ligase ligand. 1-(4-Pip-Ph)-DHP-dione can be used for synthesis of PROTAC HPK1 Degrader-2 (HY-162544).
    1-(4-Pip-Ph)-DHP-dione
  • HY-138793
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine 26581-81-7 98.08%
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas.
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine
  • HY-W586822
    N-Methylated pomalidomide 1352827-50-9
    N-methylated pomalidomide (Pomalidomide-methyl), a derivative of Pomalidomide (HY-10984), is a cereblon (CRBN) ligand. N-methylated pomalidomide is unable to recruit CRBN that can be used as a negative control for Pomalidomide. N-methylated pomalidomide can be used to synthesize PROTAC.
    N-Methylated pomalidomide
  • HY-14658B
    (R)-Thalidomide 2614-06-4 99.80%
    (R)-Thalidomide ((R)-(+)-Thalidomide) is the R-enantiomer of Thalidomide. (R)-Thalidomide has psychomotor stabilizing properties.
    (R)-Thalidomide
  • HY-W730665
    CRBN ligand-838 2654822-43-0
    CRBN ligand-838 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-838 can be linked to a target protein ligand via a linker to form a PROTAC.
    CRBN ligand-838
Cat. No. Product Name / Synonyms Application Reactivity
Ligands for E3 Ligase Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.